Patients with progressive or relapsed adult ALL remain curable despite failing initial treatment. Patients failing treatment can be divided into two broad categories. Patients who fail to achieve an initial complete disappearance or remission of their cancer following a complete course of remission induction chemotherapy treatment are referred to as “induction failures”.
Jul 30, 2015 · In adults, long-term disease-free survival and cure in 7% to 24% of relapsed patients generally occurs only with allogeneic SCT. 6, 9, 13, 14 Predictors for outcomes include duration of first remission, response to initial salvage therapy, ability to undergo SCT, disease burden at time of SCT, and patient age. 9.
Patients who relapse in their marrow during or just after completing initial treatment may benefit from a stem cell transplant. Patients who relapse six months or more after initial treatment can often be re-treated with more intensive chemotherapy without a transplant. Relapses most often occur in .
Over 80 percent of adult patients with newly diagnosed acute lymphoblastic leukemia (ALL) will attain a complete remission with intensive induction chemotherapy. After further consolidation therapy and maintenance chemotherapy, less than half will have long-term leukemia-free survival; the majority of adults with ALL will ultimately relapse.